Grain Laboratories is enrolling fifteen adults with elevated serum PFOS for a twelve-week NeutraOat pilot. You'll receive two PFAS panels and two wellness panels, before and after twelve weeks of daily dosing. You'll see your own before-and-after results, and we'll use the group results to decide whether NeutraOat should move into a larger study.
NeutraOat is a modified form of oat fiber (β-glucan), designed to bind PFAS in your gut before they're reabsorbed. It's food-grade, derived from oats, and built to do one thing well: capture the kinds of molecules that don't belong in your body, while leaving alone the ones that do.
PFAS molecules have a long, "greasy" tail. NeutraOat is built around microscopic hydrophobic pockets, added to oat fiber through a controlled enzymatic step, that match that geometry. Most things your body needs don't fit. Selectivity is built into the structure.
PFAS lingers in the body because the liver excretes it into bile, and the gut reabsorbs it. That enterohepatic loop recycles the same molecules for years. A binder that captures PFAS in the gut breaks that cycle and lets it leave.
A 2024 published trial of cholestyramine, a prescription bile-acid binder that works through the same gut-binding mechanism, showed roughly 60% PFOS reduction over 12 weeks at 12 g/day. Cholestyramine binds indiscriminately and is poorly tolerated. NeutraOat targets the same mechanism at 4 g/day, with selectivity engineered into the molecular structure. This pilot is the first time we're measuring it in people.
We're prioritizing firefighters and AFFF-exposed adults (about ten of fifteen slots), and reserving a handful for community-exposed participants and other elevated cases. Your most recent serum result counts; you don't need a new test to apply.
Everything happens at home. There's no clinic visit, no travel, no insurance involvement.
Two at-home kits arrive at your door. The first is a finger-prick PFAS panel from Relentless Health, measuring PFOS, PFOA, and PFHxS. The second is a comprehensive wellness panel covering thyroid, hormones, metabolic, lipid, inflammation, and nutrient markers across 40+ biomarkers. Both ship back the same day. You receive your full baseline results before dosing begins.
Four grams per day of NeutraOat, taken as two grams twice daily, pre-meal. We ship enough for the full duration.
A five-minute online diary covering tolerability, adherence, and any GI symptoms. Anything flagged for concern routes directly to Grain Labs and, where appropriate, to your PCP.
The same paired kits go out again, followed by a thirty-minute conversation about how it went: what worked, what didn't, what you'd pay for it. You'll see how your numbers changed against your own baseline. An optional follow-up sample at week sixteen captures post-dose dynamics.
No copays, no deductibles, no out-of-pocket costs. Twelve weeks of NeutraOat, two paired PFAS panels, and two comprehensive wellness panels, all covered by Grain Laboratories. Time is the only contribution we ask for.
Food-grade NeutraOat, batch-tested, shipped to you.
Baseline and week-12 finger pricks via Relentless Health. PFOS, PFOA, and PFHxS, run at the same lab with the same method, directly comparable.
40+ biomarkers at baseline and week 12, covering thyroid, hormones, metabolic, lipid, inflammation, and nutrient markers.
Grain Laboratories is the Boston-based company developing NeutraOat. We design the protocol, supply the product, run participant communications, and analyze the results. Our research partner at the University of Alberta produces the pilot batch.
Relentless Health handles PFAS testing. The same paired methodology and instrument are used at baseline and week 12, so your before-and-after numbers are directly comparable.
Trevor Klee, Founder & CSO, Grain Laboratories
Reach us via the NeutraOat contact form →
Available throughout the program. Adverse-event reports route to Grain Labs and, where appropriate, your primary care physician.
If something here doesn't answer what you're wondering, get in touch.
A modified oat-fiber product designed to capture PFAS in the gut before it gets reabsorbed. Food-grade, taken twice daily for twelve weeks.
Oatmeal would help a bit, but NeutraOat goes beyond that. We start from a refined fraction of oat fiber called β-glucan, and run it through a controlled enzymatic step that adds hydrophobic pockets matched to the geometry of PFAS molecules. Plain oatmeal doesn't have that engineering.
NeutraOat is not certified organic. Glyphosate residue is a fair question for any oat-derived product, and we've thought carefully about it.
The starting material for NeutraOat is purified oat β-glucan, not whole oats or oat flour. Two factors make residue carryover unlikely:
The pilot batch has not yet been tested for glyphosate, AMPA, or a broad pesticide panel. The starting β-glucan has been tested by our supplier for heavy metals, microbial contamination, and gluten. The certificate of analysis is available on request. Pesticide panel testing (including glyphosate-specific LC-MS/MS) will be part of the release specification for commercial batches, and those results will be published.
No. NeutraOat is a non-prescription product, not FDA-approved as a treatment. This pilot is the first human study of it.
We think it will, but we're not certain. Measuring that is the whole point of the pilot. The reason we're optimistic: cholestyramine, a prescription bile-acid binder that works through the same gut-binding mechanism, reduced PFOS by roughly 60% in a published 2024 trial. NeutraOat is engineered to do the same job in food-grade form, at a lower dose, with selectivity built into the structure.
NeutraOat is modified oat fiber. It moves through the digestive tract in about three hours, isn't absorbed into the bloodstream, and leaves the body intact. The most likely side effects are the same as with any fiber: mild GI effects like gas or bloating. The protocol has been reviewed by independent clinicians, and an independent clinician advises the program throughout.
Most medications are fine. GLP-1 agonists, like Mounjaro or Ozempic, are fine. So are over-the-counter medications, like Advil or Tylenol.
The only medications that aren't fine are ones where small dose changes can be dangerous clinically. The following disqualify you from participation:
If you take something not on this list and you're unsure, apply anyways. The application form screens for medications and conditions that would interact with the product.
Yes. We're pretty sure NeutraOat won't interfere with your meds or supplements, but we'd rather be safe than sorry.
Take NeutraOat 1 to 2 hours apart from any medications, prescription or over-the-counter, and from any vitamins or supplements. This is the same dose-separation practice that's standard with prescription bile-acid binders like cholestyramine.
NeutraOat is taken twice a day before meals, so for most people the easiest routine is to move other pills to a different part of the day. We'll walk through your schedule on the intake call.
No. Your individual results go to you. Nothing is shared with your employer, your department, or any third party without your explicit written consent.
Yes. You'll see your baseline PFAS panel and wellness panel before dosing starts, and your week-12 results when they return. Both sets are yours to keep, and we'll walk you through what the numbers mean if you'd like.
No. We're not selling or sharing your information, and we won't add you to a marketing list. The data is collected for the pilot. That's it.
Participation is independent of any litigation. We don't share participant information with attorneys, employers, or any third party. If you have active legal questions, check with your lawyer before applying.
Apply anyway. If you'd otherwise qualify, we'll cover a new PFAS panel through Relentless Health as part of intake. That becomes your baseline.
Same rules apply: adult, serum PFOS at or above 4 ng/mL, no active GI conditions, no current bile-acid binder use. If they meet the criteria, send them to apply.
We want you to know exactly what you're signing up for. This is a discovery cohort, meaning a small, structured study designed to generate signal and tolerability data ahead of a larger trial. Honesty about scope is part of the deal.
The screener checks eligibility, asks about commitment and any GI conditions, and collects your contact details. If you qualify, you'll be invited to book a fifteen-minute intake call to walk through consent and finalize enrollment.